Svetlana P Ermakova

159 Pr-t 100-letiya Vladivostoka, Vladivostok, 690022

Pacific Institute of Bioorganic Chemistry FEB RAS

Phone: (74232)-310705

E-mail: svetlana_ermakova@hotmail.com

Objective:

Scientist, Biochemistry

Education:

1995 – 2002    Pacific Institute of Bioorganic Chemistry Far East Branch of the

Russian Academy of Sciences, Dr. Phil. (Ph.D.) 2002

1987 – 1990    PhD student, Moscow State Academy of Light Industry

(now State University of Design and Technology), Moscow

1982 – 1987     Moscow State Academy of Light Industry

(now State University of Design and Technology), Moscow

1972 – 1982    High school, Orsk, Russia

Experience:

Senior Scientist, 2006 – present

Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia

The Chemistry of Enzymes

Hormel Fellow, 2003 – 2006

The Hormel Institute, University of Minnesota, Austin, MN, US

The Cellular and Molecular Biology

Junior scientist, 1995 – 2003

Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia

The Chemistry of Enzymes

PhD student, 1987 – 1990

Moscow State Academy of Light Industry, Moscow, Russia

Research Skills:

Extensive knowledge of purification a proteins and polysaccharides from seaweeds. Studies of biological activities of proteins and polysaccharides from seaweeds.

Studies of the molecular mechanisms and the signal transductions regulated by natural compounds.

Publications:

1.                  Zviagintseva T.N., Makar'eva T.N., Ermakova S.P., and Eliakova L.A. (1998) Synthesis of p-nitrophenyl laminarioligosides via transglycosylation reaction catalyzed by endo-1,3-beta-D- glucanase from marine mollusk. Bioorg Khim. (Moscow) 24. 219-23.

 2.                  Ermakova S.P., Burtseva Y.V, Sova V.V., Kratchun V.V., and Zvyagintseva T.N. (2001) Proteins of brown seaweeds as inhibitors of endo-1-->3-beta-D-glucanases of marine invertebrates. Biochemistry (Moscow). 66. 188-94.

 3.                  Yermakova S.P., Sova V.V., and Zvyagintseva T.N. (2002) Brown seaweed protein as an inhibitor of marine mollusk endo-(1-->3)-beta-D-glucanases. Carbohydr Res. 337. 229-37.

 4.                  Ermakova S., Choi B.Y., Choi H.S., Kang B.S., Bode A.M., and Dong Z. (2005) The intermediate filament protein vimentin is a new target for epigallocatechin gallate. J Biol Chem. 280. 16882-90.

 5.                  Berigina N.S., Burtseva Iu., Ermakova S.P., Sova V.V., Pivkin M.V., and Zviagintseva T.N. (2005) Metabolites of marine organisms as regulators of O-glycosylhydrolases. Prikl Biokhim Mikrobiol. (Moscow) 41. 402-8.

 6.                  Choi B.Y., Choi H.S., Ko K., Cho Y.Y., Zhu F., Kang B.S., Ermakova S.P., Ma W.Y., Bode A.M., and Dong Z. (2005) The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat Struct Mol Biol. 12. 699-707.

 7.                  Ermakova S.P., Kang B.S., Choi B.Y., Choi H.S., Schuster T.F., Ma W.Y., Bode A.M. and Dong Z. (2006) EGCG Overcomes Resistance to Etoposide-induced Cell Death by Targeting the Molecular Chaperone GRP78. Cancer Research. 66. 18. 9260-9269.

 8.                  Cho Y.Y, Yao K, Bode A.M., Bergen HR 3rd, Madden B.J., Oh S.M., Ermakova S., Kang B.S., Choi H.S., Shim J.H., Dong Z. (2007) RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem. 282. 11. 8380-92.

 9.                  Li M, He Z, Ermakova S, Zheng D, Tang F, Cho YY, Zhu F, Ma WY, Sham Y, Rogozin EA, Bode AM, Cao Y, Dong Z. (2007) Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation. Cancer Epidemiol Biomarkers Prev., Mar;16(3). 598-605.

 10.              Zykova T.A., Zhu F., Zhai X., Ma W.Y., Ermakova S.P., Lee K.W., Bode A.M., Dong Z. (2008) Resveratrol directly targets COX-2 to inhibit carcinogenesis. Mol Carcinog. 47. 10. 797.

 11.              Kusaykin M.I., Bakunina I.Y., Sova V.V., Ermakova S.P., Kuznetsova T.N., Besednova N.N., Zaporozhets T.N., Zvyagintseva T.N. (2008) Structure, biological activity, and enzymatic transportation of fucoidans from the brown seaweeds. Biothechnol. J. 3. 7. 904-915. Review.

 12.              Lee N.Y., Ermakova S.P., Zvyagintseva T.N., Kang K.W., Dong Z., Choi H.S. (2008) Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells. Food Chem. Toxicol. 46. 5. 1793

 13.              Lee N.Y., Ermakova S.P., Choi H.K., Kusaykin M.I., Shevchenko N.M., Zvyagintseva T.N., Choi H.S. (2008) Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells. Mol Carcinog. 47. 8. 629

 14.              Verigina N.S, Kiseleva M.I, Ermakova S.P., Sova V.V., Zvyagintseva T.N. (2009) O-glycosylhydrolases of embryos of the sea urchin Strongylocentrotus intermedius and effect of some natural substances on their biosynthesis. Zh Evol Biokhim Fiziol (Russia). 45. 1. 53-58.

 15.               Moon H.J., Lee S.H., Ku M.J., Yu B.C., Jeon M.J., Jeong S.H., Stonik V.A., Zvyagintseva T.N., Ermakova S.P., Lee Y.H. (2009) Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts. Eur. J. Dermatol. 19. 2. 129-134.

 16.               Moon H.J., Park K.S., Ku M.J., Lee M.S., Jeong S.H., Imbs T.I, Zvyagintseva T.N., Ermakova S.P., Lee Y.H. (2009) Effect of Costaria costata Fucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, and Protein. J. Nat. Prod. 72. 1731-34.