Laboratory of Chemistry of Noninfectious Immunity

Head of the Lab:


CHERNIKOV Oleg, Ph.D.
Tel. +7 (423) 231-07-19, chernikov@piboc.dvo.ru

Research Team:

LUKYANOV Pavel á
Professor, Dr. of Sciences,
Principal Researcherá
Tel. +7-914-735-34-56,ápaluk@mail.ru

CHIKALOVETS Irina
Ph.D., Associate Professor, á
Senior Researcher
ivchik@piboc.dvo.ru

MOLCHANOVA Valentina
Ph.D., Senior Researcher
molchanova@piboc.dvo.ru

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BULGAKOV Alexanderá
Ph.D., Senior Researcher

VAKHRUSHEVA Nina
Principal Engineer

ZAKHARKINA Lidiaá
Senior laboratory assistent

KOBELEV Stanislaváá
Principal Engineer



Marine biological resources are rich of new physiologically active substances including polysaccharides of various chemical structure and lectins. Lectins are carbohydrate-binding proteins specifically recognizing and reversibly binding to certain carbohydrate glycoconjugate structures without change in covalent structure of the recognized glycosyl ligands. This distinguishes lectins from other carbohydrate binding proteins and enzymes, and makes them invaluable tools in biomedical and glycoconjugate research. Lectins are involved in various biological processes, such as fertilization, cell adhesion, cell signaling, cell growth and differentiation. It is usually assumed that the lectins perform a protective function in the system of innate immunity. Marine invertebrates lectins exhibit various biological activities such as antifungal, mytogenic, antiproliferative and antiviral. They can be used as diagnostic tools for the investigation of the early cell-membrane alterations and carbohydrate changes that accompany tumor and immune processes.
Marine polysaccharide recently attracted attention because they are not toxic and reveal interesting biological properties (immunomodulatory, anti-inflammatory, radio-protective, antiviral, antimicrobial, anti-tumor, wound-healing and etc.). They can find application in medical practice, food and cosmetic industries.
Our Lab mainly focuses on isolation of the lectins and polysaccharides from marine invertebrates. We investigate the chemical and biological properties. Study the role in marine organisms.

The main goals:
Structure and function of biological macromolecules (polysaccharides, lectins and carbohydrate-protein complexes). Molecular bases of immunity.

Highlights and perspectives:
Characterization of the structure of the lectin MTL from the mussel Mytilus trossulus
Crystallization and 3D structure of the lectin CGL from the mussel Crenomytilus grayanus
Further investigation of biological properties of polysaccharide Neomytilan from C. grayanusá